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,低濃度のタモキシフェンの投与によりRas遺伝子変異をモザイクに発現させたとき,正常な細胞にかこまれたがん変異細胞においてTMRMのシグナルが減弱する, すなわち,ミトコンドリア内膜の膜電位が低下することがわかった

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Nejnovější tweety od uživatele Reddit Books (@Reddit_Books). The official Twitter of the /r/books reddit community. Would you like to do a Reddit AMA? message us! RedditBooksAMA@gmail.com

同じSであっても、MIC値が低い薬剤ほど低濃度で薬剤の効果が期待できます。ただしこれはあくまでin vitroであって、in vivoでは臓器移行性等も加味して考える必要があると思いますが・・・・ CLSIでは有効性の判定基準を菌別に詳細に設定しています。